Ki values of NAIP peptides and XIAP in caspase-3 and caspase-7 inhibition assays
| Peptides | Caspase-3 (nm) | Caspase-7 (nm) |
|---|---|---|
| XIAP | 16 ± 6 | 49 |
| B123xt | 14 ± 5 | 50 |
| B1 | >1000 | |
| B2 | 10 ± 6 | |
| B3 | 185 ± 15 | |
| B12 | >1000 | |
| B23 | 287 ± 20 |
Ki values were determined as described in Materials and Methods. Under the chosen conditions, the observedKi approximates half of the IC50value (nanomolar) obtained from the curve fitting.