Table 3.

E2F1, pRb, and ppRb immunostainings correlated with macrophages, whereas only pRb and ppRb correlated with virus in the simian model of HIVE

SIVE	A or T	Midfrontal cortex		Caudate		Putamen
SIVE	A or T	gp110	HAM56	gp110	HAM56	gp110	HAM56
E2F1	A	−0.1725	0.8357**	−0.2334	0.7887**	0.7601**	0.8936**
	T	−0.1253	0.8101**	−0.2417	0.7803**	0.7137**	0.9169**
pRb	A	0.7917**	0.6568**	0.4656*	0.7983**	0.5382*	−0.5082*
	T	0.7890**	0.6593**	0.6525**	0.8050**	0.5526*	−0.4712
ppRb	A	0.8898**	0.6253**	0.7329**	0.5473**	0.7272**	0.7130**
	T	08052**	0.6769**	0.6374**	0.3661	0.7076**	0.6508**

Fluorescent immunostainings for E2F1, pRb, and ppRb were quantified in midfrontal cortex, caudate, and putamen of SIVE macaques. For each cell cycle protein, double-label immunofluorescent staining for the SIV viral envelope protein gp110 (columns 1, 3, and 5) and HAM56 for activated macrophages (columns 2, 4, and 6) were also quantified in the same fields as the cell cycle proteins. Pearson's correlation coefficients (r) were determined for each cell cycle protein compared with either SIV virus (gp110) or macrophages (HAM56) staining area (A) or total fluorescence (T). The rvalues are indicated in the table. *p ≤ 0.01; **p≤ 0.001.