Table 1.

Effects of i.v. doses of nicotine on intragastric pressure, tonic contraction of the fundus, motility of the antrum, and mean arterial blood pressure

Dose of nicotine (nmol/kg)Effects of nicotine on
IGPFundusaMMIBP
02.0  ± 1.0%0.1  ± 0.43.2  ± 8.04.0  ± 3.0
56.5−6.0  ± 2.1%1-a−0.5  ± 0.32.1  ± 6.22.1  ± 6.2
113−10.0  ± 3.2%1-a−0.9  ± 0.41-a4.0  ± 6.5−3.0  ± 5.0
226−12.0  ± 2.0%1-a−1.6  ± 0.31-a8.0  ± 5.19.0  ± 4.3
452−16.0  ± 2.4%1-a−2.0  ± 0.41-a−18.5  ± 4.01-a23.0  ± 4.11-a
904−18.0  ± 4.1%1-a−2.8  ± 0.91-a−27.9  ± 6.31-a35.0  ± 6.01-a

  • Values represent means ± SEM of 6–12 animals. Intragastric pressure (IGP) is expressed as percentage change from baseline. Fundic activity (Fundus) is expressed in terms of change in gram tension. aMMI, Antral minute motility index; blood pressure (BP) is expressed in mmHg. Under dose of nicotine, 0 corresponds to equal volume of saline.

  • ↵F1-a  p < 0.05 using ANOVA followed by Duncan's, as compared with saline controls.