Effects of bilateral cervical vagotomy on i.v. nicotine-induced changes in intragastric pressure and tonic contraction of the fundus
| Dose of nicotine (nmol/kg) | Effects of nicotine on | |
|---|---|---|
| IGP | Fundus | |
| 113 | 2.1 ± 1.8%3-a | 1.2 ± 0.53-a |
| 226 | −3.6 ± 1.0%3-a | −0.3 ± 0.93-a |
| 452 | −11.4 ± 3.2% | −2.3 ± 0.2 |
Values represent means ± SEM of three to five animals. Intragastric pressure (IGP) is expressed as percentage change from baseline. Fundic activity (Fundus) is expressed in terms of change in gram tension.
↵F3-a p < 0.05 using ANOVA followed by Duncan's, as compared with data tabulated in Tables1 and 2 obtained with first dose of nicotine in vagus nerve intact animals.