Effects of inhibition of protein synthesis, RNA synthesis, or MF transection before LTP induction
| Groups | PTP magnitude (% baseline) | τPTP (min) | fEPSP amplitude 60 min after HFS (% baseline) | τbsln (min) |
|---|---|---|---|---|
| MF LTP control (MK 801; 10-15 μm; n = 5) | 499 ± 25 | 3.5 | 187 ± 12 | N/A |
| MF LTP control (d-APV; 25 μm; n = 4) | 484 ± 40 | 2.6 | 177 ± 17 | N/A |
| Emetine (20 μm; 60 min; n = 3) before MF LTP induction | 393 ± 47 | 2.9 | 101 ± 2 n.s. | 9 |
| Actinomycin D (25 μm; 120 min; n = 4) before MF LTP induction | 531 ± 61 | 2.5 | 117 ± 4 n.s. | 33 |
| MF transection before MF LTP induction (n = 5) | 512 ± 41 | 3.1 | 130 ± 19 n.s. | 31 |
| MF transection before C/A-LTP induction (n = 3) | N/A | N/A | 208 ± 15 | N/A |
| MF transection + emetine (20 μm; 60 min; n = 4) before MF LTP induction | 513 ± 98 | 2.8 | 104 ± 5 n.s. | 10 |
n.s., Statistically not significantly different from baseline values. Control groups are the same as shown in Table 1. N/A, Not applicable.