Classification of clones and statistical analysis on filter array
| Description | GenBank accession number | Ratio |
|---|---|---|
| Intracellular signal transduction and intercellular communication | ||
| Tubby superfamily protein | NM_020245 | 1 |
| Mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate) (EMS1), transcript variant 2 | NM_138565 | 1.9 ± 0.10 |
| Cell death-inducing DFFA-like effector b | AF218586 | 3 ± 0.23 |
| Purinergic receptor P2X | U83993 | 6 ± 0.32 |
| MAPK kinase 1 | L11284 | 8.7 ± 0.96 |
| Cadherin 18, type 2 | XM_011214 | 8.8 ± 0.3 |
| c-Ha-ras | J00277 | 10.3 ± 0.56 |
| Gene regulatory proteins | ||
| SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily a, member 4 | XM_009081 | 3.1 ± 0.69 |
| Inhibitor of DNA binding, dominant negative helix-loop-helix protein | XM_046179 | 4 ± 1.1 |
| Helicase/primase complex protein | AF487338 | 6 ± 1.25 |
| Ribosomal protein L7a | BE559788 | 6.3 ± 0.67 |
| α Enolase 1 | NM_001428 | 9.9 ± 1.06 |
| Free radical modulation proteins | ||
| Carbonyl reductase 1 | XM_009749 | 4.5 ± 1.25 |
| Cu/Zn SOD1 | X02317 | 6.8 ± 1.1 |
| Intracellular or intercellular transport proteins | ||
| Apolipoprotein D | XM_049984 | 2.1 ± 0.25 |
| Transferrin | XM_002793 | 7.5 ± 1.46 |
| Phosphotidylinositol transfer protein β | NM_012399 | 9.6 ± 0.86 |
| Mitochondrial related | ||
| Cytochrome b | AF254896 | 7.1 ± 0.68 |
| mRNA containing 12S rRNA sequence | AY012136 | 17.3 ± 3 |
| Metabolism | ||
| Phosphotriesterase-related | AI819400 | 2.3 ± 0.17 |
| Uridine-cytidine kinase 1 (UCK1) | XM_033385 | 2.7 ± 0.54 |
| Glutamate dehydrogenase 1 | NM_005271 | 5.9 ± 0.68 |
| Calpain, small subunit 1 | XM_009338 | 18.2 ± 1.50 |
| Cytoskeleton regulation | ||
| RNB6 | XM_007244 | 2.9 ± 0.46 |
| Uncharacterized mRNAs with complete open reading frame | ||
| Clone image 5261941 | BC035097 | 1.5 ± 0.23 |
| FLJ10743 | NM_018201 | 1.9 ± 0.51 |
| FLJ12123 | AK022185 | 1.9 ± 0.19 |
| FLJ10994 | AK001856 | 2.4 ± 0.6 |
| LOC257167 | XM_173054 | 2.6 ± 1.15 |
| FLJ12387 similar to kinase light chain | BC034373 | 3.1 ± 0.31 |
| FLJ14220 | AK024282 | 5.1 ± 1.14 |
| FLJ12936 | AK022998 | 3.5 ± 0.66 |
| FLJ 14936 | NM_032864 | 4.4 ± 0.17 |
| FLJ31340 | AK055902 | 5.4 ± 1.22 |
| MAC3077 | XM_018160 | 5.7 ± 0.51 |
| FLJ33905 | AK091224 | 6.1 ± 1.06 |
| Similar to FK506 binding protein 9 | BC007443 | 6.5 ± 1.32 |
| FLJ13658 | AK023720 | 6.5 ± 0.87 |
| Secreted protein of unknown function | BC008823 | 8.5 ± 1.45 |
| AD-003 protein | XM_052723 | 14.4 ± 0.74 |
| Clone MGC: 33424, IMAGE: 5266665 | BC036526 | 30.9 ± 2.4 |
| EST clones | ||
| EST | BI463414 | 2.9 ± 0.49 |
| EST | BM706879 | 3.1 ± 1.07 |
| EST | AA584851 | 4.1 ± 0.35 |
| EST | AA084569 | 6.7 ± 2.09 |
| EST | AV755263 | 7.6 ± 1.58 |
| EST | BG013057 | 8.7 ± 0.96 |
| EST | AI457597 | 9.9 ± 0.81 |
| EST | AI720416 | 10.3 ± 1.64 |
| EST | AA828749 | 11.2 ± 2.3 |
| EST | AA828970 | 11.2 ± 1.99 |
| EST | AA923791 | 21.8 ± 1.71 |
| EST | AA488746 | 27.5 ± 2.43 |
| Unidentified | ||
| 1 | 1.7 ± 0.47 | |
| 2 | 3 ± 0.84 | |
| 3 | 5 ± 0.8 | |
| 4 | 5.2 ± 0.58 | |
| 5 | 6.1 ± 0.4 | |
| 6 | 10.2 ± 1.65 | |
| 7 | 13.7 ± 2.31 | |
| 8 | 20.8 ± 2.17 | |
| 9 | 21 ± 3.43 | |
| 10 | 22.7 ± 1.31 | |
The ratio represents the relative abundance of each oxidized RNA species in AD frontal cortex and refers to the fold change by normalizing the value of each band to the least intense band (i.e., tubby superfamily).