Table 1.

Brain Aβ40 and Aβ42 in formic acid extracts from drug-treated and vehicle-treated young PS/APP mice

nAβ40       Aβ42
Picomoles of Aβ per gram of tissue
Gelsolin-treated mice
 Set 11-a
  Vehicle7199  ± 29226  ± 46
  Gelsolin689  ± 2295  ± 30
(p  = 0.02)(p  = 0.049)
 Set 21-b
  Vehicle9429  ± 43644  ± 80
  Gelsolin7190  ± 33314  ± 60
(p  = 0.01)(p  = 0.008)
GM1-treated mice
 Set 11-a
  Vehicle7199  ± 29226  ± 46
  GM16112  ± 23104  ± 28
(p  = 0.03)(p  = 0.04)

  • Data are presented as mean ± SEM.

  • ↵F1-a Aβ was extracted by the four-step method (Kawarabayashi et al., 2001).

  • ↵F1-b Aβ was extracted by the two-step formic acid extraction method (Janus et al., 2000).