Lack of antagonism by NBQX, LY303070, or CGS19755 on the Tat-induced [3H]ACh release from superfused human or rat cortical synaptosomes
| Human synaptosomes | Rat synaptosomes | |
|---|---|---|
| Tat (1 nm) | 78.6 ± 5.3 | 36.2 ± 3.6 |
| Tat (1 nm) + NBQX (10 μm) | 71.8 ± 6.8 | 27.4 ± 6.3 |
| Tat (1 nm) + LY303070 (10 μm) | 73.4 ± 5.3 | 32.4 ± 4.3 |
| Tat (1 nm) + CGS19755 (10 μm) | 67.5 ± 7.2 | 31.9 ± 5.2 |
Antagonists were added 8 min before Tat and maintained until the end of the superfusion period. Results are expressed as the percentage of increase over basal. Data are means ± SEM of three to five experiments run in triplicate.