Table 3.

Effects of the mGluR antagonists MPEP and CPCCOEt on the Tat-induced [3H]ACh release from human cortical synaptosomes

Basal release Tat-induced release
Control 66.9 ± 10.3
MPEP (1 μm) 8.9 ± 6.6 19.7 ± 5.1a
CPCCOEt (5 μm) 9.9 ± 4.4 25.2 ± 3.6a
MPEP (1 μm) + CPCCOEt (5 μm) 7.6 ± 3.5 24.4 ± 4.7a
  • Antagonists were added 8 min before 1 nm Tat and maintained until the end of the superfusion period. Results are expressed as the percentage of increase over basal. Data are means ± SEM of four experiments run in triplicate.

  • a p < 0.01 versus Tat.