Table 1.

Distribution of the 5-HT1A receptor G(-1019) gene polymorphism in depressed patients and control subjects from the Ontario cohort

Genotypes Alleles
Subjects N C/C C/G G/G C G
Controls 134 50 68 16 168 100
Major depression 129 30 63 36 123 135

  • Control subjects versus depressed patients: genotype, X2 = 12.79, df = 2, p = 0.0017; allele, p = 0.0006. Presence of any C allele versus absence of any C allele, p = 0.0018. Presence of any G allele versus absence of any G allele, p = 0.0158.