Age in months | Y-maze test | Active avoidance test escape latency (sec) | Light/dark test | |||||
---|---|---|---|---|---|---|---|---|
Arm entry (n) | Alternations (%) | Day 1 | Day 5 | Day 10 | Transitions (n) | Time in light (sec) | ||
4 | WT | 18 ± 1 | 70 ± 4 | 0.5 ± 0.1 | 0.7 ± 0.2 | 0.4 ± 0.1 | 6 ± 1 | 46 ± 10 |
PS2APP | 13 ± 1* | 52 ± 7* | 0.8 ± 0.1 | 0.4 ± 0.1 | 0.5 ± 0.1 | 4 ± 1 | 56 ± 21 | |
8 | WT | 18 ± 1 | 70 ± 5 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.1 | 6 ± 1 | 49 ± 9 |
PS2APP | 16 ± 2 | 61 ± 3 | 1.0 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.2 | 9 ± 1 | 60 ± 7 | |
12 | WT | 17 ± 2 | 64 ± 4 | 0.6 ± 0.1 | 0.6 ± 0.2 | 0.4 ± 0.1 | 8 ± 1 | 75 ± 8 |
PS2APP | 20 ± 2 | 63 ± 3 | 1.4 ± 0.4 | 0.7 ± 0.2 | 1.4 ± 0.6 | 8 ± 1 | 83 ± 11 | |
16 | WT | 13 ± 1 | 71 ± 4 | 0.8 ± 0.1 | 0.4 ± 0.1 | 1.9 ± 1.0 | 9 ± 1 | 81 ± 16 |
PS2APP | 19 ± 1* | 66 ± 3 | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.4 ± 0.6 | 9 ± 1 | 90 ± 11 |
Summary data taken from the Y-maze, active avoidance, and light/dark tests. All data are expressed as means ± SEM; *p < 0.05 versus age-matched controls. Escape latency data from days 1, 5, and 10 are included as a performance measure from the active avoidance test. In all groups and all time points the level of escape failures was <5%. WT, Wild type.