Mean 5-HT concentration in different nervous tissues and adrenal glands in 5-HTT+/+ mice (+/+) and 5-HTT−/− mice (−/−)
| Sciatic nerve | Plantar skin | L4/5 spinal cord | Adrenal glands | |||||
|---|---|---|---|---|---|---|---|---|
| +/+ | −/− | +/+ | −/− | +/+ | −/− | +/+ | −/− | |
| Controls (right/left) (μg/gm) | 0.4 ± 0.1 (10) | 0.1 ± 0.1 (4) | 1.3 ± 0.2 (9) | 0.7 ± 0.1 (7) | 2.4 ± 0.6 (10) | 0.7 ± 0.1 (7) | 2.4 ± 0.2 (7) | 0.3 ± 0.0 (7) |
| CCI +13 (μ/gm) | ||||||||
| OP | 0.8 ± 0.2 | 0.1 ± 0.0 | 0.7 ± 0.1 | 0.5 ± 0.1 | ||||
| CTR | 0.2 ± 0.1 (7) | 0.0 ± 0.0 (5) | 0.6 ± 0.1 (7) | 0.4 ± 0.0 (5) | 1.2 ± 0.1 (9) | 0.6 ± 0.1 (9) | 1.6 ± 0.1 (7) | 0.3 ± 0.1 (5) |
| CCI +28 (μg/gm) | ||||||||
| OP | 1.4 ± 0.3 | 0.4 ± 0.1 | 0.9 ± 0.2 | 1.0 ± 0.1 | ||||
| CTR | 0.5 ± 0.1 (9) | 0.1 ± 0.0 (9) | 0.8 ± 0.2 (7) | 0.7 ± 0.1 (8) | 1.2 ± 0.2 (7) | 0.5 ± 0.0 (5) | 1.9 ± 0.2 (9) | 0.3 ± 0.00 (9) |
Data are pooled for both sides (right/left) in unoperated animals (controls). On days 13 and 28 after CCI (CCI +13 and CCI +28), values of the sciatic nerve and the plantar skin are evaluated separately on the operated (OP) and contralateral nonoperated side (CTR); values of the L4/5 spinal cord and the adrenal glands are recruited from both sides. Data are given as means ± SEM. The number of animals tested is shown in parentheses. Also see Figure 4.