Electrophysiological characteristics of striatal spiny projection neurons and fast spiking interneurons in cortex-striatum-substantia nigra cultures
| Characteristics | Spiny projection neuron (n=16) | Fast spiking interneuron (n=7) |
|---|---|---|
| Down-state potential (mV) | −79.2 ± 1.9 | −64.5 ± 3.3** |
| Input resistance (MΩ)a | 341 ± 36 | 287 ± 60 |
| Spike amplitude (mV)b | 61.5 ± 2.4 | 57.1 ± 5.0 |
| Spike width (msec)c | 1.51 ± 0.09 | 0.83 ± 0.05 |
| AHPmax (mV) | 14.1 ± 0.8 | 17.3 ± 2.0 |
| Time to AHPmax (msec) | 8.8 ± 0.4 | 4.8 ± 0.6** |
| Latency to first spike (msec)d | 379 ± 25 | 199 ± 28 |
Results are mean ± SEM (MANOVA:F = 18.74;p = 0.001;**ANOVA on time to AHPmax:F = 33.62;p<0.0001; ANOVA on down-state potential:F = 15.03;p = 0.0019). Spike width and latency to first spike were used to classify neurons; thus, ANOVA is inappropriate on these characteristics.
↵ a Measured using depolarizing and hyperpolarizing current pulses from down-state potential.
↵ b Spike threshold to spike peak.
↵ c Action potential width measured at half of spike amplitude.
↵ d Maximal observed latency in response to 500 msec current pulses at various current strengths.