Brain region | GenBank accession number | Probe ID | mRNA | Direction of change | Percentage of change calls |
---|---|---|---|---|---|
Striatum plus cortex | X61940 | 104598_at | MKP-1 | Increase | 100 |
Striatum plus cortex | V00714 | 94781_at | Hemoglobin, α adult chain 1 | Increase | 100 |
Striatum plus cortex | J00413 | 101869_s_at | Hemoglobin, β adult major chain | Increase | 100 |
Cortex | V00722 | 103534_at | Hemoglobin, β 1 | Increase | 75 |
Cortex | V00727 | 160901_at | c-fos oncogene | Increase | 100 |
Cortex | AI854404 | 160131_at | Angiomotin like 2 | Increase | 100 |
Cortex | AI845584 | 93285_at | MAPK phosphatase-3 (MKP-3) | Increase | 75 |
Cortex | M88354 | 93381_at | Arginine vasopressin | Increase | 75 |
Striatum | D45859 | 101836_at | Protein phosphatase 1B, β isoform | Increase | 75 |
Striatum | AB028272 | 96254_at | DNAJ-heat shock protein 40 | Increase | 75 |
Striatum plus cortex | C79248 | 94689_at | Unknown | Decrease | 75 |
Cortex | L31397 | 103031_g_at | Dynamin | Decrease | 75 |
Cortex | M18775 | 102431_at | Microtubule-associated protein tau | Decrease | 75 |
Cortex | AV330064 | 161114_i_at | Unknown | Decrease | 75 |
Striatum | AJ007909 | 98525_f_at | Erythroid differentiation regulator | Decrease | 100 |
Striatum | AI451558 | 97161_at | Unknown | Decrease | 75 |
Striatum | AI153421 | 96215_f_at | Unknown | Decrease | 75 |
Striatum | D00073 | 95350_at | Transthyretin | Decrease | 75 |
Striatum | AA711516 | 96302_at | Unknown | Decrease | 75 |
Striatum | AI183202 | 92724_at | Heterogeneous nuclear ribonucleoprotein A1 | Decrease | 75 |
Samples from sodium butyrate-treated R6/2, untreated R6/2, and wild-type mice (n = 4 from each group) were analyzed for differential mRNA expression by microarray. Array data are expressed as increased or decreased based on a minimum difference call cutoff of three of four independent comparisons using samples from individual mice (see Materials and Methods). Most important in the gene array findings was that three known genes (α-and β-globin and MKP-1) were highly increased in expression. These increases in mRNAs were specific to both the striatum and neocortex and were detected in all eight array comparisons.