Effect of direct intra-BNST microinjections of 0.01, 0.02, or 0.2 nmol of N/OFQ or its vehicle (0.0) per site on food intake in rats deprived of food for 20 hr (n = 10) and in food-sated animals (n = 9)
| Dose (nmol/site) | ||||
|---|---|---|---|---|
| N/OFQ | 0.0 | 0.01 | 0.02 | 0.21 |
| Food deprived | ||||
| t (30 min) | 13.4 ± 0.5 | 13.4 ± 0.9 | 14.5 ± 0.7 | 14.9 ± 1.5 |
| t (60 min) | 20.9 ± 1.2 | 22.1 ± 1.3 | 22.1 ± 1.7 | 22.2 ± 2.9 |
| Food sated | ||||
| t (30 min) | 0.3 ± 0.2 | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.2 ± 0.2 |
| t (60 min) | 0.3 ± 0.2 | 0.3 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.2 |
Access to food was given 30 min after N/OFQ injection, and food intake was measured after 30 and 60 min. Difference from controls was not significant. t, Time.