Behavior | gria1 KOa | BLA lesionsb | gria2 KO | CeA lesionsb |
---|---|---|---|---|
Pavlovian conditioning | Normal | Normal | Normal | Normal |
Conditioned approach | Normal | Normal | Impaired | Impaired |
Pavlovian-to-instrumental transfer | Normal | Normal | Impaired | Impaired |
CR | Impaired | Impaired | Enhanced | Normal |
Primary reinforcement (instrumental) | Enhanced | Normalc | Enhanced | Normalc |
Amphetamine-potentiation of CR | Not tested | Normald | Impaired | Impairede |
Second-order schedules of reinforcement | Impaired | Impairedf | Not tested | Normalg |
The effects of gria1 deletion resemble BLA lesions, whereas gria2 deletion resembles lesion of the CeA. Pavlovian conditioning is defined as the ability to use a cue as a signal for reward availability. Responding for primary reinforcement as assessed using a VI schedule of reinforcement for food reward.
↵ a Mead and Stephens, 2003.
↵ b Everitt et al., 2000.
↵ c Holland and Gallagher, 2003.
↵ d Burns et al., 1993.
↵ e Robledo et al., 1996.
↵ f Everitt et al., 1989; Whitelaw et al., 1996.
↵ g Everitt et al., 2003.