RBA | ||
---|---|---|
Ligand | ERα | ERβ |
17β-Estradiol | 100 | 100 |
4-Hydroxytamoxifen | 36 | 43 |
Raloxifene | 34 | 76 |
GW-5638 | 5 | 8 |
STX | 4.3E-6 | 9.0E-6 |
Relative binding affinities (RBA) are expressed as a percentage of the potency of 17β-estradiol. Under the experimental conditions described in Materials and Methods, 17β-estradiol was found to have an IC50 of 5 nm for ERα and 3 nm for ERβ.