Effects of NPY on bicuculline-induced evoked thalamic oscillations in vitro
| Parameters | Control (n = 7) | NPY (n = 7) | Washout (n = 7) | p |
|---|---|---|---|---|
| 01(%) | 81 ± 3 | 62 ± 5* | 70 ± 4 | <0.05 |
| τ of oscillation (sec) | 2.26 ± 0.32 | 1.30 ± 0.22* | 1.79 ± 0.32 | <0.05 |
| Interburst period (msec) | 310 ± 5 | 351 ± 12* | 316 ± 7 | <0.05 |
| Total spikes (per sweep) | 350 ± 120 | 100 ± 20 | 290 ± 50 | <0.1 |
| Number of bursts | 18 ± 3 | 11 ± 1*** | 16 ± 2 | <0.001 |
No. of bursts, Number of bursts in each evoked oscillatory episode; Interburst period, interval between consecutive bursts; Total spikes, spikes per episode, averaged across 20 episodes. The time constant (τ) of decay for oscillations is obtained from the autocorrelogram and is a measure of oscillation duration. This measure, and OI, which reflects the overall contribution of oscillatory power to the autocorrelation function, are defined in Materials and Methods and in previous publications (Cox et al., 1997; Huntsman et al., 1999; Sun et al., 2002a). *p<0.05; ***p<0.001.