Table 1.

Effects of lidocaine inactivation of vSUB on cocaine self-administration behavior

Responding (responses/2 hr)
Group Control Pretreatment
Saline (n = 7) 94 ± 4 71 ± 13
Lidocaine (n = 6) 113 ± 11 105 ± 14
  • Data are group mean ± SEM. Control data (no vSUB infusions) were from the cocaine self-administration sessions before the pretreatment sessions. Responding was reinforced contingent on an FR 5 schedule except that the first cocaine infusion was delivered after the first response. The two groups showed similar baseline responding. The responding after vSUB lidocaine (100 μg/side) was similar to that after vSUB saline (Tukey's test; p > 0.05).