The effect of the GAT-1 antagonist N0711 on eIPSCs evoked by minimal stimulation and sIPSCs in dentate gyrus granule cells of wt and δ−/− mice
| wt | wt + N0711 | δ−/− | δ−/− + N0711 | |||
|---|---|---|---|---|---|---|
| Soma | Dendrite | Soma | Dendrite | Dendrite | Dendrite | |
| eIPSCs | ||||||
| Amplitude (pA) @Vh = −70mV | −180.5 ± 44.1 | −135.5 ± 32.7 | −205.2 ± 47.8 | −162.8 ± 39.8 | −125.5 ± 7.7 | −110.5 ± 4.7 |
| RT10-90% (msec) | 0.49 ± 0.05 | 2.00 ± 0.35 | 0.44 ± 0.03 | 1.87 ± 0.33 | 3.87 ± 0.33 | 3.99 ± 0.35 |
| τw (msec) | 7.6 ± 0.4 | 28.3 ± 3.4 | 8.2 ± 0.5 | 54.3 ± 7.5* | 16.3 ± 2.1 | 18.7 ± 1.7 |
| sIPSCs | ||||||
| Frequency (H2) | 7.5 ± 2.0 | 6.7 ± 2.0 | 5.4 ± 0.7 | 6.1 ± 1.1 | ||
| Amplitude @Vh = −70 mV | −48.7 ± 5.2 | −51.6 ± 5.3 | −43.5 ± 3.6 | −41.7 ± 2.4 | ||
| RT10-90% (msec) | 0.326 ± 0.02 | 0.358 ± 0.01 | 0.308 ± 0.01 | 0.332 ± 0.005 | ||
| τw (msec) | 4.97 ± 0.62 | 5.74 ± 0.64 | 4.17 ± 0.29 | 4.16 ± 0.18 | ||
| Number of cells | 4 | 4 | 4 | 4 | 4 | 4 |
↵* denotes p < 0.05, paired two-tailed t test, between corresponding stimulation sites under control conditions and in the presence of 10 μm N0711.