Amyloid burden, curvature ratios, and neuritic densities measured under craniotomies and remote sites
| Control antibody remote | Control antibody window | Anti-Aβ antibody remote | Anti-Aβ antibody window | |
|---|---|---|---|---|
| Amyloid burden | 10.78 ± 4.83 | 12.74 ± 9.42 | 9.57 ± 5.85 | 1.93 ± 1.61* |
| (n = 6) | (n = 6) | (n = 10) | (n = 10) | |
| Curvature ratio (all time points) | 0.945 ± 0.026 | 0.946 ± 0.024 | 0.932 ± 0.034 | 0.982 ± 0.010* |
| (n = 6) | (n = 6) | (n = 10) | (n = 10) | |
| 4 d curvature ratio | 0.947 ± 0.05 | 0.950 ± 0.04 | 0.925 ± 0.07 | 0.981 ± 0.04* |
| (n = 2) | (n = 2) | (n = 4) | (n = 4) | |
| 32 d curvature ratio | 0.943 ± 0.06 | 0.941 ± 0.06 | 0.935 ± 0.06 | 0.982 ± 0.02* |
| (n = 3) | (n = 3) | (n = 4) | (n = 4) | |
| SMI-32 density | 66.00 ± 3.52 | 66.65 ± 3.36 | 65.61 ± 3.10 | 66.03 ± 4.44 |
| (n = 6) | (n = 6) | (n = 10) | (n = 10) |
Curvature ratio for untreated nontransgenic neurites, 0.983 ± 0.009. *p≤0.01, significantly different. Amyloid burden and SMI-32 density are means ± SDs, and curvature ratios are medians ± median absolute deviations. n denotes number of animals.