Biophysical parameters for activation and fast inactivation
| Voltage dependence of activation | Voltage dependence of fast inactivation | Recovery from fast inactivation | |||||||
|---|---|---|---|---|---|---|---|---|---|
| V½(mV) | k(mV) | n | V½ (mV) | k (mV) | n | τ1 (msec) | τ2 (msec) | n | |
| WT | −23.6 ± 1.2 | 7.4 ± 0.3 | 17 | −64.1 ± 1.1 | −5.7 ± 0.1 | 18 | 3.9 ± 0.5 | 96 ± 16 | 19 |
| (83 ± 2%) | (17 ± 2%) | ||||||||
| l1656M | −17.4 ± 1.5† | 8.3 ± 0.2* | 8 | −68.2 ± 1.7* | −7.1 ± 0.4††† | 8 | 5.6 ± 0.6 | 60 ± 14 | 7 |
| (87 ± 3%) | (13 ± 3%) | ||||||||
| R1657C | −16.6 ± 1.3*** | 8.3 ± 0.2† | 18 | −67.1 ± 1.4 | −5.2 ± 0.1** | 18 | 1.9 ± 0.2** | 29 ± 3†† | 15 |
| (76 ± 2%**) | (24 ± 2%**) | ||||||||
Values significantly different from WT are marked with asterisks or daggers: *p < 0.05; **p < 0.005; ***p < 0.0005; †p < 0.01; ††p < 0.001; †††p < 0.0001.