Current responses of wild-type and C-terminal truncated mutants of TRPV1 channel to heat, capsaicin, and pH 5
| Channel | IHEAT at 47°C, nA (n) | Temperature threshold, °C | ICAPS at 25–47°C nA | IpH5nA | Q10 median (range) | Temperature range |
|---|---|---|---|---|---|---|
| WT | 5.7 ± 0.6 (47) | 41.5 ± 0.4 (25) | 1.5 ± 0.4 (29) | 2.3 ± 0.4 (15) | 25.6 (6.3–143) | 44–47°C (26) |
| CΔ31 | 6.5 ± 0.9 (34) | 38.6 ± 0.7 (22) | 1.1 ± 0.3 (24) | 1.3 ± 0.7 (8) | 22.1 (4.9–127) | 44–47°C (23) |
| CΔ42 | 6.9 ± 0.9 (24) | 32.5 ± 0.5 (21) | 2.4 ± 0.5 (13) | 3.3 ± 0.7 (9) | 13.2 (5.5–97) | 38–42°C (22) |
| CΔ72 | 2.3 ± 0.2 (57) | 28.6 ± 0.5 (50) | 0.6 ± 0.1 (29) | 0.7 ± 0.1 (14) | 4.7 (1.8–22) | 31–35°C (50) |
| CΔ78 | 0.6 ± 0.2 (29) | 0.3 ± 0.1 (23) | 0.2 ± 0.1 (14) | 1.7 (1.3–7.5) | 27–32°C (25) | |
| CΔ104 | 0.4 ± 0.1 (16) | 0 (10) | 0.5 ± 0.3 (10) | 1.3 (1.2–1.4) | 27–32°C (11) |