Clinical classification of G93A SOD1 transgene-induced disease progression
| Group classification | Clinical signs |
|---|---|
| Presymptomatic | Full mobility and no observable difference in behavior from age-matched controls |
| Onset | Observation of abnormal gait or hindlimb weakness |
| End stage | Overall muscle wasting and complete hindlimb paralysis
indexed as an inability to right themselves in a 30 sec time window; typically accompanied by paralysis of at least one front limb |