Wild-type | Ala53Thr mutant | |||
---|---|---|---|---|
TH | Nissl | TH | Nissl | |
Saline | ||||
Controls | 12,084 ± 143 | 16,468 ± 476 | 12,576 ± 674 | 15,632 ± 668 |
Overexpressors | 12,068 ± 184 | 16,046 ± 305 | 12,115 ± 138 | 15,982 ± 300 |
Paraquat | ||||
Controls | 9,462 ± 296** | 13,522 ± 493* | 8,010 ± 330** | 12,192 ± 772* |
Overexpressors | 13,012 ± 304 | 17,270 ± 112 | 10,904 ± 274 | 15,966 ± 780 |
The number of TH-immunoreactive and Nissl-stained neurons was counted in the substantia nigra pars compacta of mice injected with either saline or paraquat. Data (means ± SEM; n = 5) were compared in transgenic animals overexpressing human α-synuclein versus non-overexpressing controls. Two lines of transgenic mice were used: one expressed the wild-type protein and the other expressed Ala53Thr mutant α-synuclein. *p < 0.05 and **p < 0.01 versus the corresponding saline-treated group.