Effects of topical lysolecithin treatment on afferent fiber numbers
| Nerve | Treatment | Side | Average number of axons per 292 mm2 EM image | |
|---|---|---|---|---|
| A-fibers | C-fibers | |||
| Sciatic | Lysolecithin | Ipsi | 6.8 ± 1.5 | 45.1 ± 9.0 |
| Lysolecithin | Contra | 7.9 ± 2.2 | 42.9 ± 8.9 | |
| Sham | Ipsi | 6.7 ± 3.3 | 39.3 ± 7.3 | |
| Saphenous | Lysolecithin | Ipsi | 10.1 ± 0.5 | 60.1 ± 2.0 |
| Lysolecithin | Contra | 11.8 ± 0.2 | 62.9 ± 1.9 | |
| Sham | Ipsi | 9.7 ± 0.3 | 57.3 ± 1.3 | |
EM images were analyzed to count profiles characteristic of C-fiber axons or A-fiber axons that were either still myelinated or had been demyelinated to varying degrees. No differences were apparent in the number of A-fiber or C-fiber axons between lysolecithin-treated and control animals. Ipsi, Ipsilateral; Contra, contralateral.