Tissue Cu and Zn levels in Znt3 wild-type (n = 6) and knock-out (n = 6) mice
| Metal | ||||||
|---|---|---|---|---|---|---|
| Zinc | ||||||
| Tissue | ZnT3+/+ | ZnT3-/- | p | ZnT3+/+ | ZnT3-/- | p |
| Plasma | 16.74 ± 0.58 | 14.47 ± 0.39 | 0.011 | 10.95 ± 0.50 | 10.14 ± 0.19 | 0.155 |
| (15.60-19.39) | (12.82-15.34) | (9.62-12.24) | (9.41-10.58) | |||
| Cerebral cortex | 11.77 ± 0.24 | 10.29 ± 0.14 | 0.0007 | 3.99 ± 0.11 | 3.88 ± 0.14 | 0.548 |
| (11.12-12.56) | (9.79-10.68) | (3.58-4.29) | (3.47-4.42) | |||
| Cerebellum | 9.72 ± 0.51 | 10.93 ± 0.46 | 0.106 | 3.73 ± 0.90 | 4.65 ± 0.44 | 0.617 |
| (7.70-11.33) | (9.49-12.44) | (3.61-9.51) | (3.70-6.66) | |||
| Heart | 13.79 ± 0.99 | 12.24 ± 0.89 | 0.273 | 4.65 ± 0.33 | 4.39 ± 0.26 | 0.547 |
| (10.04-17.40) | (9.22-14.85) | (3.63-5.51) | (3.52-5.45) | |||
| Liver | 24.27 ± 0.84 | 27.28 ± 1.18 | 0.066 | 6.50 ± 1.46 | 5.85 ± 0.92 | 0.716 |
| (21.45-27.18) | (23.83-31.58) | (4.07-13.50) | (3.88-10.19) | |||
| Kidney | 16.18 ± 0.80 | 15.06 ± 0.28 | 0.233 | 3.57 ± 0.17 | 3.33 ± 0.07 | 0.217 |
| (14.32-18.93) | (13.98-15.87) | (3.22-4.19) | (3.09-3.51) | |||
| Pancreas | 21.96 ± 0.82 | 23.17 ± 1.61 | 0.521 | 1.06 ± 0.04 | 1.04 ± 0.02 | 0.740 |
| (20.12-25.74) | (17.62-28.38) | (0.91-1.16) | (0.97-1.09) |
Values are means ± SEM (range); microgram per gram of wet weight, except for plasma, which is in micromoles per liter. p values are for t tests (two-tailed).