Voltage-dependent properties of various Kv4.2-encoded K+ currents
| Activation | Inactivation | |||
|---|---|---|---|---|
| V1/2 (mV) | Rate | V1/2 (mV) | Rate | |
| COS | ||||
| Wild type (n = 5) | -6.1 ± 3.5 | 22.5 ± 0.8 | -70.3 ± 2.3 | 8.2 ± 1.1 |
| Wild type plus CaMKII Δ316 (n = 4) | -13.7 ± 2.7 | 21.8 ± 1.4 | -68.3 ± 1.7 | 5.3 ± 0.5 |
| S438D-S459D (n = 4) | -8.4 ± 2.6 | 21.2 ± 1.7 | -68.7 ± 2.1 | 5.8 ± 1.5 |
| CHO | ||||
| Wild type (n = 4) | -1.4 ± 2.9 | 21.9 ± 0.7 | -60 ± 1.8 | 4.1 ± 0.3 |
| S438A-S459A (n = 4) | -7.8 ± 2 | 20.5 ± 1.3 | -63.5 ± 0.7 | 7.1 ± 0.2 |
| S438A-S459A plus CaMKII Δ316 (n = 5) | -4 ± 3 | 21.7 ± 0.3 | -59.5 ± 1.7 | 4.6 ± 0.4 |
| Oocytes | ||||
| Wild-type (n = 4) | -18.0 ± 2 | 15.3 ± 0.4 | -60.3 ± 0.9 | 3.5 ± 0.1 |
| S438A-S459A (n = 10) | -18.6 ± 0.8 | 15.2 ± 0.3 | -61.6 ± 0.9 | 3.5 ± 0.1 |
| S438D-S459D (n = 9) | -17.4 ± 0.9 | 15.4 ± 0.5 | -64.1 ± 1.4 | 3.5 ± 0.1 |
| Wild type plus CaMKII Δ316 (n = 16) | -21.2 ± 1 | 15.2 ± 0.1 | -67.2 ± 0.6 | 3.6 ± 0.1 |
Multigroup comparisons for each parameter within three groups showed no significant difference (ANOVA; p > 0.05).