Effects of various compounds on the elimination rate of [125I]Aβ(1-40) from rat brain
| Inhibitor | Apparent elimination rate constant (kapp,el) (percentage of control) |
|---|---|
| Control | 100.0 ± 5.0 |
| RAP (5 μm) | 109.9 ± 7.1 |
| l-Tyrosine (2 mm) | 98.0 ± 14.3 |
| Fucoidan (100 μg/ml) | 98.5 ± 10.0 |
| Thiorphan (1 mm) | 66.0 ± 5.0* |
| AG1024 (100 μg/ml) | 110.0 ± 11.3 |
| Anti-IGFIR (100 μg/ml) | 101.9 ± 7.0 |
RAP, fucoidan, thiorphan, AG1024, and anti-IGFIR were each administered simultaneously with [125I]Aβ(1-40) and [14C]inulin. l-Tyrosine was preadministered before [125I]Aβ(1-40) and [14C]inulin administration. The clearance was evaluated as kapp,el. Each value represents the mean ± SEM (n = 3-8). *p < 0.01, significantly different from the control.