Striatal dopamine levels in DD and reserpine-treated mice
| Animal | Treatmenta | DA content (ng/mg protein) | DA percentage |
|---|---|---|---|
| DD (n = 2) | l-Dopa | 28.58 ± 12.4 | 10.54 |
| DD (n = 6) | Saline | 0.73 ± 0.19 | 0.27 |
| Control (n = 4) | Reserpine | 1.84 ± 0.15 | 0.68 |
| Control (n = 4) | Vehicle | 271.07 ± 26.6 | 100 |
Dopamine (DA) concentrations were measured by HPLC. Values are expressed as mean ± SEM.
↵ a Adult DD mice were treated daily with l-dopa (50 mg/kg). Twenty-three hours after their last treatment, l-dopa or an equivalent volume of saline was administered 1 hr before mice were killed. Control mice received either reserpine (5 mg/kg, s.c.) or 0.1% acetic acid in distilled water (vehicle) 13 hr before the experiment.