Table 1.

Physiological characteristics of synapsin TWT and TKO mice

	TWT	TKO
Initial evaluation and general screen
Skin color	Normal	Normal
Body tone	Normal	Normal
Lacrimiation/palperbral closure	Normal	Normal
Exopthalmus	Normal	Normal
Convulsions/tremor	Absent	Present
Heart rate	Normal	Normal
Respiration rate	Normal	Normal
Posture/tail elevation	Normal	Normal
Barbering/hair loss	Absent	Absent
Orientation and reflexive behavior
Visual orientation to object	Normal	Normal
Visual placement	Normal	Normal
Whisker reflex	Normal	Delayed^*
Eye reflex	Normal	Delayed^*
Pinna (ear) reflex	Normal	Delayed^*
Postural and righting reflexes
Postural (vertical)	Normal	Normal
Postural (horizontal)	Normal	Abnormal^*
Contact righting	Normal	Normal
Spinocerebellar function
Forepaw grasp/strength	Normal	Normal
Hindpaw grasp/strength	Normal	Normal
Hindpaw coordination	Normal	Abnormal^*
Wire hang (duration)	52.0 ± 7.5 sec	18.1 ± 2.2 sec^**
Pole climbing down
Latency	10.2 ± 0.9 sec	1.83 ± 1.1 sec^**
Duration	8.4 ± 1.9 sec	16.9 ± 4.5 sec
Pole climbing up
Latency	8.4 ± 3.2 sec	4.8 ± 1.5 sec
Duration	12.1 ± 3.4 sec	22.4 ± 4.5 sec
Pole walking
Latency	10.0 ± 1.2 sec	16.1 ± 2.3 sec^*
Duration	13.5 ± 5.2 sec	31.9 ± 4.9 sec^**

Numerical data are expressed as means ± SEM. The data were analyzed with an independent t test. n = 10 mice per genotype. ^*p< 0.05; ^**p< 0.01.