Table 2.

Average ± SEM number of NR2B-labeling immunogold particles per synapse in layer 2/3 of A1

Terminal Presynaptic At PSD Near PSD Synaptic Extrasynaptic Spine/Dendrite
Normal (n = 153) 1.95 ± 0.19 0.20 ± 0.05 0.12 ± 0.04 0.16 ± 0.05 0.48 ± 0.08 0.18 ± 0.04 0.97 ± 0.15
SNHL (n = 175) 2.85 ± 0.22 0.51 ± 0.06 0.56 ± 0.07 0.38 ± 0.05 1.45 ± 0.11 0.60 ± 0.10 1.48 ± 0.18
p values 0.0022 0.0001 <0.0001 0.0018 <0.0001 0.0001 0.0336
  • n denotes the number of synapses analyzed for each condition. Synaptic category was calculated by summing the values in presynaptic, at PSD, and near PSD categories. p values were obtained by performing nonpaired Student's t test, two-tailed.