Dose effects of 3,4-DiAP on caffeine-induced attacks
| Pretreatment | 5 mg/kg caffeine | 15 mg/kg caffeine | ||
|---|---|---|---|---|
| Percentage of attacks | Duration (min) | Percentage of attacks | Duration (min) | |
| Saline | 84 | 71 ± 5(36/43) | 93 | 91 ± 5(42/45) |
| 1.0 mg/kg 3,4-DiAP | 82 | 65 ± 6(14/17) | 100 | 86 ± 8(16/16) |
| 2.5 mg/kg 3,4-DiAP | 47** | 46 ± 10(8/17) | 78 | 77 ± 7(14/18) |
| 5.0 mg/kg 3,4-DiAP | 6**** | 60 (1/18) | 16**** | 107 ± 9(3/18) |
Values in parentheses represent the number of mice with attacks/number of mice tested. Asterisks denote significant differences from saline pretreatment as determined by logistic regression (**p < 0.01; ****p < 0.0001). 3,4-DiAP had no effect on duration compared with saline pretreatment. Data for 5 mg/kg 3,4-DiAP also appear in Table 1. Duration is expressed as mean ± SEM.