Effects of various agents with 5-HT1A receptor activity on respiration after SCI
| f(bpm) | Vt (ml) | Ve (ml/min) | |
|---|---|---|---|
| Pre-SCI | 182.9 ± 8.5 | 2.94 ± 0.09 | 537.7 ± 29.6 |
| Predrug (2 weeks after SCI) | 160.7 ± 7.3† | 2.50 ± 0.08† | 404.3 ± 26.8† |
| 8-OH DPAT (125 μg/kg) | 173.9 ± 6.3 | 2.77 ± 0.06*† | 479.7 ± 15.6*† |
| 8-OH DPAT (250 μg/kg) | 183.7 ± 5.0* | 3.03 ± 0.06* | 555.1 ± 17.9* |
| p-MPPI (3 mg/kg) plus 8-OH DPAT (250 μg/kg) | 158.7 ± 7.3† | 2.43 ± 0.06† | 380.7 ± 24.9† |
| Buspirone (1.5 mg/kg) | 180.7 ± 5.6* | 2.91 ± 0.08* | 524.8 ± 21.7* |
| Repeated-measures ANOVA | p < 0.001 | p < 0.001 | p < 0.001 |
Respiratory responses to hypercapnic stimulus (7% CO2) for rats with severe hemicontusion injury (50 mm; n = 12) at preinjury baseline or 2 weeks after SCI under predrug, 8-OH DPAT (125 μg/kg), 8-OH DPAT (250 μg/kg), p-MPPI (3 mg/kg), p-MPPI (3 mg/kg) plus 8-OH DPAT (250 μg/kg), or buspirone (1.5 mg/kg). All numbers are presented as mean ± SEM. The asterisk indicates a significant difference from predrug on post hoc Tukey's test (p < 0.05), and the dagger symbol indicates a significant difference from 8-OH DPAT (250 μg/kg) on post hoc Tukey's test (p < 0.05) after significant differences were found on repeated-measures ANOVA.