m∞ | h∞ | |||
---|---|---|---|---|
V50 (mV) | k | V50 (mV) | k | |
Wild-type | −54.8 ± 0.4 | 7.4 ± 0.1 (43) | −85.5 ± 0.8 | −7.2 ± 0.2 (29) |
F161L | −53.3 ± 1.0 | 7.2 ± 0.2 (11) | −82.3 ± 0.9* | −5.9 ± 0.1 (7)** |
E282K | −53.4 ± 0.7 | 7.9 ± 0.2 (15)** | −83.9 ± 1.2 | −6.3 ± 0.1 (7)* |
C456S | −59.9 ± 0.9** | 7.4 ± 0.1 (26) | −85.1 ± 1.0 | −6.8 ± 0.1 (16) |
G499S | −54.2 ± 0.6 | 7.4 ± 0.2 (13) | −85.5 ± 1.6 | −7.2 ± 0.4 (8) |
P648L | −53.9 ± 0.5 | 7.5 ± 0.2 (19) | −81.7 ± 1.7* | −6.7 ± 0.3 (8) |
R744Q | −53.9 ± 0.6 | 7.4 ± 0.1 (15) | −84.2 ± 2.0 | −6.6 ± 0.3 (7) |
A748V | −56.2 ± 1.1 | 7.1 ± 0.2 (9) | −85.5 ± 1.4 | −6.6 ± 0.2 (5) |
G773D | −51.8 ± 1.0** | 8.0 ± 0.2 (15)** | −82.2 ± 1.1* | −8.0 ± 0.4 (8)* |
G784S | −54.0 ± 0.6 | 7.3 ± 0.2 (21) | −85.4 ± 1.6 | −6.6 ± 0.3 (10) |
R788C | −52.5 ± 0.9* | 7.9 ± 0.2 (13)* | −83.2 ± 1.1 | −8.5 ± 0.2 (7)** |
G773D-R788C | −53.0 ± 0.9 | 7.4 ± 0.1 (7) | −84.8 ± 1.5 | −8.5 ± 0.5 (7)** |
V831M | −52.2 ± 0.8** | 7.5 ± 0.1 (14) | −86.5 ± 1.3 | −6.7 ± 0.2 (8) |
G848S | −54.6 ± 0.8 | 7.1 ± 0.1 (16) | −83.3 ± 2.1 | −6.6 ± 0.3 (7) |
D1463N | −52.8 ± 0.8 | 7.4 ± 0.2 (8) | −85.8 ± 0.7 | −6.3 ± 0.4 (4) |
The values of V50 and k were calculated for each cell and then averaged. Data shown are mean ± SEM from the number of cells shown in parentheses. Statistically significant differences (determined with Student's t test) are marked with a single asterisk if p < 0.05 and with a double asterisk if p < 0.01.