Control | Otx2-CKOa | Otx2-CKO; Nkx2.2−/−b | |
---|---|---|---|
E12.5 | 1715 ± 47 (3) | 1202 ± 120 (3) | 1659 ± 54 (3) |
Values represent the mean ± SD. Values in parentheses show the number of animals examined. *p < 0.05;**p < 0.01; t test. The percentage changes are obtained by comparing mutant results with control results (100% by default).
↵ a The number of Pou4f1+ neurons is reduced by 30% in Otx2-CKO embryos compared with control or Otx2-CKO; Nkx2.2−/− embryos (p < 0.05).
↵ b There is no significant difference between control and Otx2-CKO; Nkx2.2−/− embryos.