Table 2.

Expected block of K+ channels in microglia

Durg (concentration used) Kv1.2 [Kd (% block)] Kv1.3 [Kd (% block)] Kv1.5 [Kd (% block)] Kv1.6 [Kd (% block)] SK4 [Kd (% block)]
4-Aminopyridine (5 mm) 590 μm (89%) 195 μm (96%) 270 μm (95%) 1500 μm (77%)
Charybdotoxin (50 nm) 14 nm (78%) 2.6 nm (95%) > 7000 nm > 7000 nm 2 nm (96%)
Agitoxin-2 (5 nm) 4 pm (>99.9%) 40 pm (99%)
α-Dendrotoxin (50 nm) 17 nm (75%) 20 nm (71%)
  • References: Grissmer et al., 1994; Garcia et al., 1997; Cahalan et al., 2001; Schlichter and Khanna, 2002; Chandy et al., 2004.