Brain levels of citalopram in C57BL/6J, 129/Sv, DBA/2J, and BALB/c mice given different doses of the drug intraperitoneally
| Dose of citalopram (mg/kg) | C57BL/6J | 129/Sv | DBA/2J | BALB/c |
|---|---|---|---|---|
| 1.25 | 0.15 ± 0.03 | ND | 0.12 ± 0.04 | ND |
| 2.5 | 0.34 ± 0.09* | 0.48 ± 0.16 | 0.25 ± 0.08*,# | 0.40 ± 0.06 |
| 5.0 | 0.99 ± 0.24 | 1.33 ± 0.39 | 1.00 ± 0.10 | 0.87 ± 0.32* |
| 10.0 | ND | 3.32 ± 0.62 | 2.95 ± 0.26 | 3.26 ± 0.87 |
| 20.0 | ND | ND | 5.75 ± 0.46 | ND |
At the end of the behavioral test, 37-40 min after citalopram injection, C57BL/6J (n = 8-10), 129/Sv (n = 9-10), DBA/2J (n = 8-10), and BALB/c (n = 5-10) mice (the same as in Fig. 2) were killed. Brain levels of citalopram were determined as described in Materials and Methods. Data are means ± SD. *p < 0.05 versus 129/Sv; #p < 0.05 versus BALB/c (Tukey-Kramer's test). ND, Not determined.