Table 1.

cPGES sense and antisense oligonucleotides

ODN Sequence Base pairs
AS1 5′-TGCAGAAGCAGGCTGCAT-3′ 52-69
AS2 5′-GTACCACTTTGCAGAAGC-3′ 61-78
AS3 5′-CCTTCGGTCGTACCACTT-3′ 70-87
S1 5′-ATGCAGCCTGCTTCTGCA-3′ 52-69

  • cPGES sense and antisense oligonucleotides were tested with intrathecal applications for downregulation of cPGES. The base pairs indicate the position of the oligonucleotides in the rat cPGES cDNA sequence.