Fractions | DMI | Fluoxetine | Reboxetine | Mirtazapine | Carbamazepine | Moclobemide | Fluphenazine | Haloperidol | Clozapine | Risperidone |
---|---|---|---|---|---|---|---|---|---|---|
LBD | 68.63 ± 18.79 | 218.35 ± 33.45 | 29.17 ± 12.96 | 8.97 ± 2.29 | 0.28 ± 0.18 | 0.46 ± 0.43 | 205.41 ± 34.03 | 61.99 ± 7.71 | 110.07 ± 18.64 | 11.46 ± 3.08 |
HBD | 16.05 ± 3.35 | 23.46 ± 2.87 | 9.41 ± 1.11 | 12.19 ± 1.96 | 0.08 ± 0.06 | 0.20 ± 0.16 | 15.53 ± 8.26 | 28.14 ± 9.58 | 47.45 ± 8.87 | 9.80 ± 3.96 |
Sucrose density fractions were prepared as described in Materials and Methods. Drug concentrations were determined by HPLC. Results are expressed as specific concentrations (micromoles per milligram of protein) and represent the mean ± SD of four independent experiments. Fractions 3-6 represent LBD fractions; fractions 8-12 represent HBD fractions.