Parameters of slow inactivation
| Channel | Voltage dependence of slow inactivation | Entry into slow inactivation at −10 mV | Recovery from slow inactivation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| τfast | τslow | n | τfast | τslow | n | ||||||||
| V1/2 (mV) | a(mV) | n | s | % | s | % | s | % | s | % | |||
| WT plus β1 | −46.2 ± 4.5 | 5.6 ± 0.8 | 12 | 0.79 ± 0.06 | 73 ± 8 | 19.6 ± 4.1 | 27 ± 8 | 5 | 0.85 ± 0.03 | 48 ± 3 | 40.5 ± 8.2 | 47 ± 4 | 6 |
| R859C plus β1 | −46.1 ± 3.8 | 6.4 ± 1.0 | 13 | 0.81 ± 0.07 | 77 ± 10 | 20.6 ± 1.2 | 23 ± 10 | 5 | 0.63 ± 0.1* | 42 ± 4* | 141.7 ± 10.2* | 57 ± 4* | 6 |
| WT plus R859C plus β1 | NDa | NDa | NDa | NDa | NDa | NDa | 0.80 ± 0.13 | 56 ± 2* | 59.7 ± 10.7* | 39 ± 2* | 4 | ||
↵aNot determined because the voltage dependence of slow inactivation and entry into slow inactivation were not affected by the R859C mutation.
The asterisk indicates a statistically significant difference from wild-type (WT) α plus β1 at p < 0.05.