τd,w (ms) | Peak amplitude (pA) | |||||
---|---|---|---|---|---|---|
α3(H126R) | α3(H126H) | Rat | α3(H126R) | α3(H126H) | Rat | |
Control | 17.6 ± 1.6 | 16.3 ± 0.3 | 20.7 ± 1.3 | 31.1 ± 2.7 | 26.4 ± 5.7 | 26.4 ± 2.0 |
100 nm zolpidem | 26.4 ± 2.2** | 23.5 ± 0.6** | 32.6 ± 1.9** | 32.1 ± 2.9 | 26.4 ± 6.6 | 27.3 ± 2.0 |
1 μm zolpidem | 23.4 ± 0.5** | n.t. | 26.6 ± 1.6** | 53.9 ± 1.6* | n.t. | 44.6 ± 4.8* |
IPSC duration and peak amplitude was measured from averaged isolated spontaneous IPSCs as described in Materials and Methods from TC neurons at P11–P14. Thalamic slices were obtained from α3(H126R) mutant mice (n = 12), their wild-type controls [α3(H126H); n = 4], and rat (n = 11). Significance assessed by two-tailed t test;
n.t., Not tested.
↵*p < 0.05,
↵**p < 0.01.