Table 1.

Sleep and wakefulness characteristics during 24 h in male and female 5-HTT−/− and 5-HTT+/+ mice treated neonatally with saline, pCPA, or WAY 100635

	W		SWS		REMS
	males	females	males	females	males	females
5-HTT−/−
Saline 2 weeks
Amounts (min)	618.8 ± 14.4	667.4 ± 19.5	679.7 ± 11.4	627.5 ± 16.9	141.5 ± 4.5^**	145.0 ± 4.6^**
Episodes (absolute value)	373.9 ± 21.8^**	277.0 ± 24.1^***	597.9 ± 15.1	381.6 ± 22.1^***	157.3 ± 5.2^**	122.0 ± 10.0^^,^*
n	6	4	6	4	6	4
pCPA 2 weeks
Amounts (min)	641.0 ± 24.8	723.2 ± 27.1^***	688.7 ± 24.3	618.2 ± 29.6^***	110.4 ± 4.7^*	98.0 ± 3.1^**
Episodes (absolute value)	318.2 ± 23.2	259.7 ± 12.3^***	580.8 ± 28.4	365.2 ± 24.1^***	107.9 ± 7.0^*	89.3 ± 3.2^*
n	9	4	9	4	9	4
WAY 100635 2 weeks
Amounts (min)	698.9 ± 11.4^*	716.7 ± 62.8	600.2 ± 12.4^*	589.3 ± 62.3	141.0 ± 4.8	134.0 ± 3.5
Episodes (absolute value)	356.2 ± 24.7	256.2 ± 20.9^***	578.4 ± 10.9	384.5 ± 46.7^***	145.0 ± 10.9	104.6 ± 7.6^***
n	5	4	5	4	5	4
Saline 4 weeks
Amounts (min)	588.1 ± 27.5	682.5 ± 18.9^***	712.8 ± 29.1	612.3 ± 17.1^***	139.1 ± 4.3^**	145.2 ± 3.3^**
Episodes (absolute value)	357.3 ± 20.6^**	288.7 ± 23.6^**	651.2 ± 25.7	383.4 ± 29.3^***	167.7 ± 8.1^**	135.1 ± 6.2^^,^*
n	6	7	6	7	6	7
WAY 100635 4 weeks
Amounts (min)	582.0 ± 38.1	674.6 ± 27.5^***	738.8 ± 36.1	642.7 ± 27.9^***	119.3 ± 3.4^*	122.7 ± 1.0^*
Episodes (absolute value)	377.9 ± 21.9	281.7 ± 23.9^***	661.0 ± 42.8	427.0 ± 31.6^***	134.5 ± 13.8^*	113.4 ± 7.3
n	6	7	6	7	6	7
5-HTT+/+
Saline 2 weeks
Amounts (min)	637.2 ± 20.0	707.1 ± 31.1^***	705.9 ± 29.0	634.3 ± 23.8^***	96.9 ± 4.0	97.9 ± 2.2
Episodes (absolute value)	294.5 ± 39.1	231.5 ± 31.7^***	598.4 ± 28.0	338.4 ± 37.6^***	86.0 ± 7.9	85.0 ± 9.7^***
n	4	4	4	4	4	4
pCPA 2 weeks
Amounts (min)	594.1 ± 10.7	749.0 ± 24.9^***	748.6 ± 14.1	610.3 ± 23.9^***	97.3 ± 5.7	80.7 ± 1.1^^,^**
Episodes (absolute value)	286.5 ± 24.6	224.0 ± 34.8	590.5 ± 26.4	253.7 ± 23.8^***	86.5 ± 7.1	69.0 ± 7.1^***
n	4	3	4	3	4	3
Saline 4 weeks
Amounts (min)	667.7 ± 32.5	716.3 ± 18.5	665.3 ± 28.1	629.2 ± 17.1	106.9 ± 7.9	94.4 ± 6.7
Episodes (absolute value)	245.5 ± 17.5	181.5 ± 12.3^***	594.2 ± 33.7	378.5 ± 49.5^***	117.2 ± 20.1	70.4 ± 11.7^***
n	4	4	4	4	4	4
WAY 100635 4 weeks
Amounts (min)	708.5 ± 32.5	773.8 ± 31.7	631.5 ± 30.8	572.1 ± 28.1	100.0 ± 5.0	94.1 ± 4.9
Episodes (absolute value)	310.4 ± 28.4	194.7 ± 37.6^***	602.7 ± 47.9	263.5 ± 38.6^***	125.8 ± 15.3	74.2 ± 6.7^***
n	5	4	5	4	5	4

The data are given as mean ± SEM.
↵*p < 0.05, significant difference for treatment (Fisher’s test);
↵**p < 0.05, significant difference for genotype in mice treated with saline (Fisher’s test);
↵***p < 0.05, significant difference for gender (Fisher’s test).