Perinatal lethality of Unc5c−/− mice on the C57BL/6J background
| Unc5c+/+ | Unc5c+/− | Unc5c−/− | |
|---|---|---|---|
| B6 congenica | 20 (29%) | 48 (71%) | 0 |
| F2 B6/SJLb | 16 (27%) | 32 (54%) | 11 (19%) |
Mice heterozygous for the Unc5c mutation were bred to C57BL/6J (B6) mice for 10 generations to create the congenic line B6.Unc5c. B6.Unc5c+/− mice were intercrossed, and resulting offspring were examined for ataxia and genotyped. Alternatively, B6.Unc5c+/− mice were mated to SJL/J mice to create F1 Unc5c+/− mice, which were intercrossed to generate F2 mice on a segregating B6/SJL background. The number of mice for each genotype surviving to 3 weeks is shown for each cross.
↵aχ2= 19.63; p < 0.001.
↵bχ2= 0.69; p < 1.0.