Brain areas activated during the comparison of fMRI signal change evoked by post-treatment high pain on placebo and control sides
| fMRI signal change | Area (Brodmann area) | Z score | Number of voxels in cluster | Peak coordinate (x, y, z) |
|---|---|---|---|---|
| Within mask | ||||
| P > C | Right thalamus | 3.54 | 34 | 2, -14, 8 |
| Right anterior insula | 3.43 | 47 | 46, 20, -4 | |
| Left SII (2, 40) | 3.28 | 83 | -62, -26, 24 | |
| Left thalamus | 3.21 | 33 | -4, -12, 8 | |
| Left pons | 3.12 | 29 | -8, -32, -36 | |
| C > P | Nothing above threshold | |||
| Outside mask | ||||
| P > C | Right inferior frontal gyrus (47)/insula | 4.36 | 1717 | 56, 28, 2 |
| Right inferior parietal cortex (40) | 4.28 | 766 | 56, -50, 32 | |
| Posterior cingulate (31) | 4.22 | 801 | 8, -34, 34 | |
| Bilateral rACC | 4.03 | 578 | 4, 44, 8 | |
| Right inferior parietal cortex (40) | 4 | 263 | 62, -30, 50 | |
| Left inferior parietal cortex (40) | 3.94 | 574 | 56, -54, 46 | |
| Left middle/inferior frontal gyrus (10, 46) | 3.60 | 91 | -50, 44, 12 | |
| Right superior frontal gyrus (8) | 3.52 | 264 | 18, 32, 50 | |
| Right superior frontal gyrus (10) | 95 | 3.39 | 4, 68, 16 | |
| Left inferior frontal gyrus (44) | 23 | 3.05 | -46, 6, 26 | |
| Left inferior frontal gyrus (47) | 50 | 3.04 | -50, 20, -6 | |
| C > P | Nothing above threshold |
The threshold is set to voxel-wise p < 0.005 with 20 continuous voxels for predefined ROIs and voxel-wise p < 0.001 uncorrected with 20 contiguous voxels and cluster p < 0.05 corrected for other regions. Peak coordinates refer to the MNI atlas. P, Placebo; C, control.