Blood ethanol concentrations at recovery of the righting reflex
| Effects of 5-HTT genotype | |
|---|---|
| Genotype | |
| +/+ | 352 ± 9 |
| +/− | 329 ± 9 |
| −/− | *302 ± 14 |
| Effects of pretreatment with citalopram and fluoxetine | ||
| Dose (mg/kg) | Citalopram | Fluoxetine |
| vehicle | 344 ± 9 | 338 ± 13 |
| 10 | 372 ± 13 | 339 ± 10 |
| 20 | 352 ± 8 | 342 ± 5 |
| 30 | 340 ± 8 | *296 ± 20 |
Increased sensitivity to the sedative/hypnotic effects of ethanol in 5-HTT−/− mice was not caused by abnormal ethanol metabolism. Blood ethanol concentrations (mg/dl) at recovery of the loss of righting reflex were significantly lower in longer-sleeping 5-HTT−/− mice than 5-HTT+/+ controls (n = 7–10 per genotype). Increased sensitivity to the sedative/hypnotic effects of ethanol after high-dose fluoxetine pretreatment in nonmutant C57BL/6J mice was not caused by abnormal ethanol metabolism. Blood ethanol concentrations (mg/dl) at the recovery of the loss of righting reflex were significantly lower in longer-sleeping mice receiving 30 mg/kg fluoxetine pretreatment than vehicle-treated controls (n = 5 per dose). Citalopram pretreatment did not affect sleep time or blood ethanol concentrations (n = 8–12 per dose). Data are mean ± SEM;
↵*p < 0.05 versus +/+ or vehicle.