Activation parameters | Inactivation parameters | |||||
---|---|---|---|---|---|---|
WT/chimeric channel | Drug treatment | G½ (mV) | k | Vi½ (mV) | k | n |
Kv2.2 WT | Control | +16.0 ± 0.5 | 14.5 ± 0.4 | −26.4 ± 0.5 | 7.8 ± 0.4 | 7 |
Plus CCh | +8.6 ± 1.0a | 15.9 ± 0.9 | −44.5 ± 0.3a | 4.8 ± 0.2 | 6 | |
Kv2.2N/2.1C | Control | +23.8 ± 1.1a | 18.6 ± 1.0 | −15.1 ± 0.8 | 6.6 ± 0.7 | 6 |
Plus CCh | −13.5 ± 0.6a | 13.9 ± 0.5 | −37.5 ± 0.3a | 4.3 ± 0.2 | 6 | |
Kv2.1N/2.2C | Control | +17.5 ± 0.9 | 15.1 ± 0.7 | −29.8 ± 0.7 | 5.5 ± 0.6 | 6 |
Plus CCh | +9.8 ± 0.4a | 11.6 ± 0.2 | −35.3 ± 0.6 | 9.8 ± 0.1 | 6 | |
Kv1.5 WT | Control | +10.2 ± 1.4 | 19.1 ± 1.2 | +3.7 ± 0.8 | 14.3 ± 0.5 | 7 |
Plus CCh | +5.4 ± 0.9a | 15.3 ± 0.8 | −12.4 ± 0.4a | 9.8 ± 0.3 | 7 | |
Kv1.5N/2.1C | Control | −1.1 ± 1.1 | 11.6 ± 0.9 | −22.1 ± 0.9 | 6.1 ± 0.8 | 7 |
Plus CCh | −19.8 ± 0.6a | 14.1 ± 0.6 | −37.2 ± 0.2a | 4.1 ± 0.2 | 6 | |
Kv1.5N/2.1C (PRC) | Control | +10.7 ± 0.7 | 18.8 ± 1.2 | +11.8 ± 1.8 | 15.4 ± 0.9 | 6 |
Plus CCh | +4.8 ± 0.9a | 17.0 ± 0.8 | −7.8 ± 0.5a | 12.7 ± 0.4 | 6 |
k denotes the slope of activation or inactivation curves. CCh, Carbachol.
↵ a Significantly different (p <0.05) from respective control values.