Table 2.

Decay and recovery time constants of the SEP and hemodynamic responses under NMDA-R and AMPA-R antagonists

SEPBOLDPWICBV
P1N1P2
MK-801
    Decay14 ± 416 ± 814 ± 48 ± 412 ± 2ND
    Recovery
GYKI-53655, 5 mg/kg
    Decay<2<23 ± 1<2<2ND
    Recovery20 ± 428 ± 626 ± 1026 ± 1026 ± 10ND
GYKI-53655, 7 mg/kg
    Decay<2<2<2<23 ± 1ND
    Recovery28 ± 830 ± 830 ± 630 ± 1222 ± 8ND
GYKI-53655, 5 mg/kg (2nd)
    Decay3 ± 1<2<2NDND<2
    RecoveryNDNDNDNDNDND
  • Time (minutes) until 50% amplitude reduction between control and steady-state change, or maximum changes and maximum recovery (means ± SD; n = 5 animals per group).