Mgo2+ block properties of NR1/2D and cortical NMDA receptors at −55 mV
| Parameter | NR1/2D receptors | Cortical NMDA receptors | ||
|---|---|---|---|---|
| Measured | Modeled | Measured | Modeled | |
| IC50 (μm) | 425 | 116 | ||
| KD,app (μm) | 483 | 412 | 136 | 116 |
| k+,app (μm−1 s−1) | 7.40 | 8.14 | 13.1 | 14.6 |
| k−,app (s−1) | 3575 | 3352 | 1788 | 1694 |
| k−,o,app (s−1) | 2119 | 1508 | ||
| k−,i,app (s−1) | 1233 | 186 | ||
All values are for the 140 Na+/125 Cs+ solution.