Variable | COMT genotype | p | |
---|---|---|---|
val/val (n = 16) | met/met (n = 15) | ||
Age | 64.3 (9.8) | 65.5 (9.6) | 0.75 |
Gender (male:female) | 11:5 | 9:6 | 0.72 |
Disease duration (years) | 3.9 (2.0) | 3.4 (1.5) | 0.41 |
UPDRS motor score | 22.2 (10.5) | 26.1 (9.4) | 0.29 |
MMSE | 28.9 (1.2) | 28.7 (0.8) | 0.59 |
Beck depression score | 6.8 (4.3) | 6.7 (4.5) | 0.99 |
NART (verbal IQ) | 113.1 (7.3) | 114.7 (6.2) | 0.50 |
Equivalent levodopa dose (mg)a | 618.8 (479.6) | 621.7 (430.6) | 0.99 |
Actual levodopa dose (mg) | 218.8 (152.6) | 313.3 (253.2) | 0.22 |
Mean (SD) tabulated unless otherwise stated. Between-group comparisons using Student's t or χ2 tests as appropriate. MMSE, Mini-Mental State Examination; NART, National Adult Reading Test.
↵aDerived from combined dopamine agonist and levodopa dose (see Materials and Methods).